APOE at the BBB
نویسندگان
چکیده
منابع مشابه
BBB building
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There is an ongoing effort to develop in vitro models for the blood-brain barrier (BBB) research and the central nervous system (CNS) drug screening. But the phenotypes of the existing in vitro models are still very remote from those found in vivo. The trouble in establishing in vitro BBB models comes from the unclear mechanism of the BBB formation and maintenance. The astrocytes have been foun...
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There is growing interest in investigating the role of subtle changes in blood-brain barrier (BBB) function in common neurological disorders, such as dementia [1,2], Alzheimer’s disease [3], type II diabetes [4] and cerebral microvascular disease [5,6]. Several studies have used dynamic contrast-enhanced MR imaging (DCE-MRI) to assess the state of the BBB in these diseases and have demonstrated...
متن کاملAPOE related alterations in cerebral activation even at college age.
BACKGROUND Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages. APOE related changes in brain activation have been recently reported for middle aged and elderly subjects. OBJECTIVE To explore APOE related alterations during cognitive activati...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2020
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.119.313627